Sunday sees the initial Wear-Tyne derby since 2024, but which side will celebrate – the Black Cats or the Magpies?
"Throughout the majority of last season, you couldn't have imagined Sunderland rising to the top flight and being competitive with Eddie Howe's Newcastle, much less being above them in the table," remarked football expert Chris Sutton.
"It is very different now, and the way Sunderland play makes me think they've got a real chance."
He is offering predictions for all 380 Premier League games this season, against AI, readers and a variety of guests.
For the upcoming matchday, he takes on England Gaming star Daniel 'Stingray' Ray.
Ray is vying for victory for the national gaming squad – the Football Association's recognised esports team – at the EA Sports FC digital Euros finals tournament, which will occur at Twickenham Stadium on Saturday.
The action will be streamed on Uefa's YouTube, Instagram Live and short-form video channels, as well as the official Twitch channel and its YouTube counterpart and England's Twitch.
What are your thoughts with their scores? Share your own guesses below.
The most popular scoreline picked for each game is used in the tables at the end of this page.
Getting the win/draw/loss right (selecting a win, draw or defeat) is worth ten points. The exact score earns 40 points.
Ray, who represents his club side and the Premier League champions as well as England, is entering the fray at the eEuros finals after passing the qualifying.
The final eight competitors will play for their countries at the finals in a knockout format, competing for a six-figure prize fund and a prestigious spot in the FC Pro World Championship Play-Ins, with Denmark's Anders Vejrgang looking to retain the title he won last year.
"I am feeling really good for it," Ray stated. "I've got a really good coach by my side and practice has been going well.
"It's always an honour to play for your country. Obviously when you are younger, you imagine doing it as an professional footballer, but when you go into this profession and there is an opportunity to represent England, putting the shirt on is something incredible.
"I beat Vejrgang 9-4 in qualifying to get here. I've played against him recently just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"For me he is the number one in the world so defeating him in a tournament like this just gives you a massive injection of confidence."
Stamford Bridge, 15:00 GMT
The Blues were impressive against the Gunners at the end of November, when they got a draw after going down to 10 men, and I was thinking here we go, they could possibly be challengers for the crown.
However, since that game, however, they were beaten physically by Leeds, looked flat against Bournemouth and this week got defeated by Atalanta in the Champions League.
So boss Enzo Maresca really needs a win here to return to winning ways, but it is a tough ask because Everton are such a potent team.
Kiernan Dewsbury-Hall and Iliman Ndiaye are playing really well and Everton have got a bit of form at the moment.
On form you would probably back the visitors, while the most sensible prediction would likely be a draw, but I'm throwing caution to the wind.
Chelsea haven't given me any compelling evidence to back them recently, but I just have a feeling they will win this match because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Anfield, 15:00 GMT
I'm attending this game and it will be intriguing to see what we get from Liverpool.
I was delighted for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday following all the stuff with Mohamed Salah this week.
Slot should not have to put up with that distraction. I know Salah has been a legend for the club but fundamentally Slot just wants to win games and there is no bias in his team selection.
They changed their tactical setup against Inter and went with a midfield diamond formation and two up top.
The media is going to be talking about whether Salah is selected for this game, but the only way he is going to be reintegrated is if he apologises.
Slot's focus will be on winning this game, but it is a tough one.
One might suggest it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are quite open too.
The Merseysiders need to get back to a consistent run of form, but I am not sure how much their exertions at the San Siro will have drained them.
I have whacked a couple of Brighton players in my FPL team, so they will probably lose now - but I do think they can get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Stadium of Light, 14:00 GMT
The Black Cats have had the week off while Newcastle had to work so hard against Bayer Leverkusen on Wednesday, only to concede a late equaliser late on.
Apart from their brilliant performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, especially straight after they've played in the Champions League.
I am expecting that trend to continue on Sunday, and their fatigue is likely to be a key element in how this game goes because of their rivals' intensity.
We saw how unwavering Regis le Bris's side are. They overpowered the Gunners, and it was incredible to watch.
Everyone talks about how Granit Xhaka has been outstanding for the Black Cats, and he has been excellent, but Noah Sadiki, who plays in midfield with him, has also been one of the top transfers and should be recognised too.
I am expecting this being the best game|most exciting fixture
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